Before you take any supplements, I would always recommend to investigate if a deficiency is likely in your individual case. You can do that with “cronometer”, free website, that helps you track your daily nutrients. Track it for 3 days, it will give you an idea.
The scientific research is a bit limited on the topic but in my opinion supplements have 3 cons: 1. Highly processed and especially always heated which can alter or reduce the bioavailability 2. the chemicals that are used to extract the nutrient out of its original form that could leach over to the actual product (marginal but could damage when taken longterm) 3. which source the company uses to extract the nutrient from (rotten food, gmo, etc)
Processed yeast would’t be much better but at least 2. and 3. wouldn’t be so prominent. Also, as far as I know vitamin toxicity has never been found from natural food, maybe because of the other vitamins balancing it out, which would be another plus for yeast. In my country (not US), we have a great product that contains only raw unheated unprocessed yeast, which works wonders. That would be ideal.