The reason I ended up going for this combo was some information from this article which said:
It is worth noting that the permeability of the blood-brain barrier is not constant. This parameter varies under different conditions, and in the case of GABA, the permeability increases considerably, for example, when nitric oxide increases, among others in response to an increased supply of arginine. Interestingly, in rats experiments, it has been observed that the administration of arginine alone causes a greater increase in GABA in the brain than the administration of this neurotransmitter directly. In contrast, the combination of GABA and arginine gave more than a 10-fold increase in the neurotransmitter in the brain, compared to the treatment with GABA1 alone.
Tenfold increase in GABA! I still want to find sources on the reliability of that study, but thats a remarkable increase in efficiency of delivery.
It really depends on the nature of the depression. I remember reading a book on use of supplements or food to balance neurotransmitters for mental health. There’s a lot to be said for self diagnosis and experimentation. Back in NZ when I first tried GABA the results were quite phenomenal.